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Our findings implicate the GPER HIF 1A axis as a master regulator of peri tumoral stromal remodeling and the fibrovascular tumor microenvironment and offer a paradigm shift for tamoxifen from a well established drug in breast cancer hormonal therapy to an alternative candidate for stromal targeting strategies in PDAC and possibly other cancers tamoxifen citrate side effects I brought it down slow and the six big plates rattled as I blasted it off my chest like nothing